Overview of nimesulide

Nimesulide-induced acute hepatitis

Nimesulide is a non-steroidal anti-inflammatory drug with a semiselective preferential inhibition of cyclooxygenase2. We present a 57 year-old patient with jaundice and increased serum aminotransferases levels, who had been treated with nimesulide for the previous 10 days. Laboratory examinations excluded other causes of acute liver injury. Liver biopsy revealed lesions compatible with drug-ind...

Nimesulide for painful osteoarthritis

Nimesulide-induced fixed drug eruption.

BACKGROUND Nimesulide is a cyclooxygenase (COX) inhibitor with a high degree of selectivity to COX-2. It is a widely used and well tolerated nonsteroidal antiinflammatory drug that also has analgesic and antipyretic properties. The most frequently reported side effects concern the gastrointestinal tract. Pruritus and skin rash are the most common cutaneous adverse reactions. There are only eigh...

Probable hypoglycaemia induced by single dose nimesulide.

Probable Hypoglycaemia Induced by Single Dose Nimesulide Sir, A 44 years non-alcoholic non-smoker healthy Hindu male from rural region was admitted with history of body ache and headache from 2-3 hours after a full vegetarian meal for which he took 2 tabs of Nimesulide (100mg each) and slept. Patient was found unconscious by the attendant after 6-8 hrs approximately and was not arousable. He wa...

Nimesulide-induced hepatitis and toxic epidermal necrolysis.